Dicyclohexylcarbodiimide → 2-(3-(Benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(benzyloxycarbonylamino)-4-oxopentanoate

HRID 526672노트

반응식

HRID 526672 반응식
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][OH:18])[C:10]=1[CH2:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:21]([O:28][C:29]([NH:31][CH2:32][C:33](=[O:39])[CH2:34][CH2:35][C:36](O)=[O:37])=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C1C=CN=CC=1.ClCCl>[CH2:21]([O:28][C:29]([NH:31][CH2:32][C:33](=[O:39])[CH2:34][CH2:35][C:36]([O:18][CH2:17][CH2:16][N:11]1[CH:12]=[CH:13][C:14](=[O:15])[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[C:10]1[CH2:19][CH3:20])=[O:37])=[O:30])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

참가 물질

6

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 113691045-(((Benzyloxy)carbonyl)amino)-4-oxopentanoic acidHCID 149562853-Benzyloxy-2-ethyl-1-(2-hydroxyethyl)pyridin-4-one

생성물 1

HCID 900688162-(3-(Benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(benzyloxycarbonylamino)-4-oxopentanoate수율 87%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

4-(Dimethylamino)pyridine (3.3 mg, 0.0274 mmol) was added to a stirred solution of 3-(benzyloxy)-2-ethyl-1-(2-hydroxyethyl)pyridin-4(1H)-one (6) (149 mg, 0.547 mmol), 5-(benzyloxycarbonylamino)-4-oxopentanoic acid (5) (145 mg, 0.547 mmol) and N,N′-dicyclohexylcarbodiimide (118 mg, 0.574 mmol) in dichloromethane (8 mL). After 24 h, the resulting suspension was filtered through cotton wool, eluting with dichloromethane. The filtrate was concentrated in vacuo and the residue was purified by flash chromatography on silica gel, eluting with ethyl acetate then methanol, to give the title compound 7 (247 mg, 87%) as a colourless oil, RF 0.7 (MeOH); δH (300 MHz; CDCl3) 7.46-7.20 (11H, m, Ar and Pyr 6-H), 6.40 (1H, d, J 9.0 Hz, Pyr 5-H), 5.97 (1H, br s, NH), 5.22 (2H, s, PhCH2), 5.09 (2H, s, PhCH2), 4.22 (2H, t, J 6.0 Hz, OCH2CH2), 4.10-3.95 (4H, m, HNCH2 and OCH2CH2), 2.71-2.50 (6H, m, CH3CH2 and C(O)CH2CH2) and 0.99 (3H, t, J 7.0 Hz, CH3) δC (75 MHz; CDCl3) 204.7, 174.3, 172.3, 156.9, 146.2, 139.4, 138.0, 136.8, 129.1, 128.9, 128.8, 128.7, 128.5, 128.4, 128.3, 117.8, 73.3, 67.3, 63.3, 51.5, 50.9, 34.4, 27.9, 19.8 and 13.5.

후처리

  1. filtrationthe resulting suspension was filtered through cotton wool
  2. washeluting with dichloromethane
  3. concentrationThe filtrate was concentrated in vacuo
  4. customthe residue was purified by flash chromatography on silica gel
  5. washeluting with ethyl acetate

출처 및 근거

ORD 기록
ord-9f0f8478c9bb409c9284d72acb72beab
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346758B2

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