Eslicarbazepine acetate → Oxcarbazepine

HRID 526674노트

반응식

C([O:4][C@@H:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]([C:16]([NH2:18])=[O:17])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]=2[CH2:6]1)(=O)C.C(O[C@H]1C2C=CC=CC=2N(C(N)=O)C2C=CC=CC=2C1)(=O)C.O[C@@H]1C2C=CC=CC=2N(C(N)=O)C2C=CC=CC=2C1.O[C@H]1C2C=CC=CC=2N(C(N)=O)C2C=CC=CC=2C1>>[O:4]=[C:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]([C:16]([NH2:18])=[O:17])[C:8]2[CH:19]=[CH:20][CH:21]=[CH:22][C:7]=2[CH2:6]1

참가 물질

반응물 4

HCID 179344Eslicarbazepine acetate

HCID 9816485Licarbazepine, (R)-

HCID 9881504Eslicarbazepine

HCID 10590023(R)-Licarbazepine Acetate

생성물 1

HCID 34312Oxcarbazepine

실험 절차

In an another embodiment, the invention provides a process for preparing (S)-(−)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, or (R)-(+)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide from (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide or (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, which are obtained by enantioselective reduction of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide or derivatives thereof in presence of boronate esters.

후처리

customIn an another embodiment, the invention provides a process

출처 및 근거

ORD 기록: ord-8e8e7db178ef4d04b51b910d62001f36
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346760B2

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