반응식
[C:1]([C:3]1([C:6]([OH:8])=O)[CH2:5][CH2:4]1)#[N:2].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C.[F:42][C:43]1[CH:48]=[CH:47][C:46]([C:49]2[C:57]3[C:52](=[N:53][CH:54]=[C:55]([F:58])[CH:56]=3)[NH:51][CH:50]=2)=[CH:45][C:44]=1[NH:59][C@H:60]1[CH2:65][CH2:64][CH2:63][C@@H:62]([NH2:66])[CH2:61]1>C1COCC1>[C:1]([C:3]1([C:6]([NH:66][C@@H:62]2[CH2:63][CH2:64][CH2:65][C@H:60]([NH:59][C:44]3[CH:45]=[C:46]([C:49]4[C:57]5[C:52](=[N:53][CH:54]=[C:55]([F:58])[CH:56]=5)[NH:51][CH:50]=4)[CH:47]=[CH:48][C:43]=3[F:42])[CH2:61]2)=[O:8])[CH2:5][CH2:4]1)#[N:2]참가 물질
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반응물 4
HCID 81531Diisopropylethylamine
HCID 27332591-Cyanocyclopropanecarboxylic acid
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 68007687(1S,3R)-N1-(2-fluoro-5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclohexane-1,3-diamine2회생성물 1
시약·촉매·용매 1
실험 절차
To a solution of 1-cyano-1-cyclopropane-carboxylic acid (0.058 g, 0.527 mmol) in THF at room temperature was added HATU (0.200 g, 0.527 mmol) followed by N,N-diisopropylethylamine (0.334 mL, 1.91 mmol). The solution was stirred for 10 minutes. (1S,3R)—N1-(2-fluoro-5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclohexane-1,3-diamine, 44e, (0.200 g, 0.584 mmol) was then added and solution stirred at room temperature for 4 hours. The mixture was concentrated in vacuo and purified via silica gel chromatography (30-60% Ethyl Acetate/hexanes) to give 80 mg of 871 as off-white solid.
후처리
- stirringsolution stirred at room temperature for 4 hours
- concentrationThe mixture was concentrated in vacuo
- custompurified via silica gel chromatography (30-60% Ethyl Acetate/hexanes)
출처 및 근거
- ORD 기록
- ord-890bcdb581834c88b166f6a4a2873ff5
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09345708B2
연결된 노트
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