Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1H-Indene-1,3(2H)-dione, 2-(3-methoxyphenyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Phthalide | HCID 6885 | — |
| 반응물 | 3-Methoxybenzaldehyde | HCID 11569 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1H-Indene-1,3(2H)-dione, 2-(3-methoxyphenyl)- | HCID 2817810 | 44.1% |
반응 단계
Sodium (1.1 g) was dissolved in anhydrous Ethanol (90 ml). This solution was added with Phthalide (4.43 g, 33.04 mmol) and m-Methoxy benzaldehyde (3.00 g, 22.03 mmol). The reaction mixture was heated for 3 hrs under reflux. The reaction mixture was concentrated in a vacuum. White solid was obtained by adding conc.HCl. And then the white solid was recrystalized in ethylacetate:hexane (=1:2) to afford the title compound (2.45 g, 44%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346749B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-a2cbd0cde9bf4e638eae4508bc2d74a6 |
| 출처 메모 | uspto-grants-2016_05 |