Hydrazine hydrate (1:1) → 5-amino-3-((4-isopropylphenyl)amino)-1H-pyrazole-4-carboxamide

HRID 527263노트

반응식

HRID 527263 반응식
[C:1]([C:3](=[C:7]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=1)SC)[C:4]([NH2:6])=[O:5])#[N:2].O.[NH2:21][NH2:22]>C(O)C>[NH2:2][C:1]1[NH:22][N:21]=[C:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:3]=1[C:4]([NH2:6])=[O:5]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 867018702-Cyano-3-((4-isopropylphenyl)amino)-3-(methylthio)acrylamide

생성물 1

HCID 867018725-amino-3-((4-isopropylphenyl)amino)-1H-pyrazole-4-carboxamide수율 66%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
75 °C

실험 절차

2-cyano-3-((4-isopropylphenyl)amino)-3-(methylthio)acrylamide (1.360 g) was suspended in 15 mL of ethanol and hydrazine hydrate (360 μL, 1.5 eq.) was added drop wise to the reaction. Reaction was then heated at 75° C. until the starting material was no longer present and confirmed via HPLC. Once starting material was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 5-amino-3-((4-isopropylphenyl)amino)-1H-pyrazole-4-carboxamide as an off white to yellow powder. The product was allowed to dry under vacuum for 1 hr (850 mg, 66% yield).

후처리

  1. customwise to the reaction
  2. customReaction
  3. custom(18 hrs), reaction
  4. customwas brought to room temperature
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-7f09d68a8a2346db8cbdc5b070dd9b44
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346792B2

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