1-(2-isopropyloxazol-4-yl)-N-methylmethanamine → N-((N-Methyl-N-((2-isopropyl-4-oxazolyl)methyl)amino)carbonyl)-L-alanine Methyl Ester

참여 물질

역할	이름	HCID	투입량
반응물	1-(2-isopropyloxazol-4-yl)-N-methylmethanamine	HCID 10820784	—
반응물	Methyl N-[(4-nitrophenoxy)carbonyl]-L-valinate	HCID 15344176	—
반응물	N-(((4-nitrophenyl)oxy)carbonyl)-L-alanine methyl ester	HCID 54298210	—
생성물	N-((N-Methyl-N-((2-isopropyl-4-oxazolyl)methyl)amino)carbonyl)-L-alanine Methyl Ester	HCID 10708114	66%

반응 단계

Using the procedure of Example 1S, but replacing 2-isopropyl-4-(((N-methyl)amino)methyl)thiazole with 2-isopropyl-4-(((N-methyl)amino)methyl)-oxazole and relacing N-(((4-nitrophenyl)oxy)carbonyl)-L-valine methyl ester with N-(((4-nitrophenyl)oxy)carbonyl)-L-alanine methyl ester provided the desired compound in 66% yield. 1H NMR (CDCl3) δ1.32 (d, 6H), 1.42 (d, 3H), 2.96 (s, 3H), 3.05 (m, 1H), 3.75 (s, 3H), 4.30 (s, 2H), 4.47 (m, 1H), 5.80 (br d, 1H), 7.46 (s, 1H). Mass spectrum: (M+H)+ =284.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05616720
출처 데이터셋	uspto-grants-1997_04
ORD ID	ord-636ca2154b8340fd87a2cf1b2626271e
출처 메모	uspto-grants-1997_04