tert-Butyl (3-amino-4-fluorophenyl)carbamate → Tert-butyl (4-fluoro-3-((5-formyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

HRID 527402

반응식

HRID 527402 반응식
[CH:1]([C:3]1[C:4]([NH:11][C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:15]=[CH:16][CH:17]=2)=[N:5][C:6]([S:9][CH3:10])=[N:7][CH:8]=1)=[O:2].NC1C=C(NC(=O)OC(C)(C)C)C=CC=1[F:33]>>[F:33][C:17]1[CH:16]=[CH:15][C:14]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:24])[CH3:23])=[CH:13][C:12]=1[NH:11][C:4]1[C:3]([CH:1]=[O:2])=[CH:8][N:7]=[C:6]([S:9][CH3:10])[N:5]=1

참가 물질

3

반응물 2

HCID 11790890tert-Butyl (3-amino-4-fluorophenyl)carbamateHCID 57343702Tert-butyl (3-((5-formyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

생성물 1

HCID 86732013Tert-butyl (4-fluoro-3-((5-formyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

실험 절차

The title compound was prepared according to the procedures described for Intermediate 50, starting from tert-butyl (3-amino-4-fluorophenyl)carbamate (58a; prepared according to the reported protocol in Kuramoto, Y. et al. J. Med. Chem. 2003, 46, 1905-1917).

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-f3f635878b4e4830a14a31b0091e706e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346801B2

연결된 노트

불러오는 중…