Acetic Anhydride → 1-(2,6-dihydroxyphenyl)ethanone O-acetyloxime

HRID 527512노트

반응식

HRID 527512 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[N:11][OH:12])[CH3:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([O:12][N:11]=[C:9]([C:3]1[C:4]([OH:8])=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH3:10])(=[O:15])[CH3:14]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 1363786461-(2,6-Dihydroxyphenyl)ethanone oxime2회

생성물 1

HCID 1363786471-(2,6-dihydroxyphenyl)ethanone O-acetyloxime수율 59.4%

실험 절차

To 1-(2,6-dihydroxyphenyl)ethanone oxime (Intermediate 8, 588 mg), acetic anhydride (1.97 ml, 20.8 mmol) was added and the reaction mixture was stirred at room temperature for 15 minutes. After the removal of the volatiles, water was added and the solid obtained was filtered and dried under high vacuum affording 437 mg of the title compound.

후처리

  1. customAfter the removal of the volatiles, water
  2. additionwas added
  3. customthe solid obtained
  4. filtrationwas filtered
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-e39ded6122ea445fb41a33891a373300
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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