Hydrochloric Acid → 3-Methyl-1,2-benzoxazol-4-ol

HRID 527513노트

반응식

HRID 527513 반응식
C(O[N:5]=[C:6]([C:8]1[C:13]([OH:14])=[CH:12][CH:11]=[CH:10][C:9]=1[OH:15])[CH3:7])(=O)C.Cl>N1C=CC=CC=1>[CH3:7][C:6]1[C:8]2=[C:13]([OH:14])[CH:12]=[CH:11][CH:10]=[C:9]2[O:15][N:5]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1363786471-(2,6-dihydroxyphenyl)ethanone O-acetyloxime2회

생성물 1

HCID 1354299403-Methyl-1,2-benzoxazol-4-ol수율 44%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To 1-(2,6-dihydroxyphenyl)ethanone O-acetyloxime (Intermediate 9, 437 mg) pyridine (4.0 ml) was added and the reaction mixture was stirred at reflux for 2 hours. After the addition of HCl (4.0 ml of a 5M aqueous solution), the mixture was extracted 3 times with Et2O and the collected organic layers were washed with HCl (1M, aqueous solution). The organic phase was dried over sodium sulphate and filtered. Evaporation afforded the title compound (137 mg).

후처리

  1. temperatureat reflux for 2 hours
  2. extractionwas extracted 3 times with Et2O
  3. washthe collected organic layers were washed with HCl (1M, aqueous solution)
  4. dry with materialThe organic phase was dried over sodium sulphate
  5. filtrationfiltered
  6. customEvaporation

출처 및 근거

ORD 기록
ord-adb870abfde14683b2b7cbd03bf0518f
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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