Hydrochloric Acid → 1-(2,6-Dihydroxyphenyl)-propan-1-one

HRID 527524노트

반응식

HRID 527524 반응식
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]COC)[C:6]=1[C:15](=[O:18])[CH2:16][CH3:17].Cl>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]=1[C:15](=[O:18])[CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22614991HCID 22614991, 화합물2회

생성물 1

HCID 116223911-(2,6-Dihydroxyphenyl)-propan-1-one수율 99.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-1-propanone (Intermediate 27, 1.7 g) was dissolved in methanol (50.0 ml) and an aqueous solution of HCl (26.7 ml, 53.5 mmol of a 2M aqueous solution) was added. The reaction mixture was refluxed for 2 hours. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (1.11 g).

후처리

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. customAfter quenching with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe gathered organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-4384d7b35b4c45d1a8745f02dca65394
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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