Acetic Anhydride → HCID 136378652, 화합물

HRID 527526노트

반응식

HRID 527526 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[N:12][OH:13])[CH2:10][CH3:11].[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([O:13][N:12]=[C:9]([C:3]1[C:4]([OH:8])=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:10][CH3:11])(=[O:16])[CH3:15]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 136378651HCID 136378651, 화합물2회

생성물 1

HCID 136378652HCID 136378652, 화합물수율 30.5%

실험 절차

1-(2,6-dihydroxyphenyl)-1-propanone oxime (Intermediate 29, 716 mg) was stirred in acetic anhydride (2.24 ml, 23.7 mmol) at room temperature for 1 hour. After removal of the volatiles, the residue was washed with water, filtered and dried. The crude compound was charged on a silica gel column (Biotage SP1 system) and eluted with Cyclohexane/EtOAc (from 100/0 to all 0/100) to afford the title compound (269 mg).

후처리

  1. customAfter removal of the volatiles
  2. washthe residue was washed with water
  3. filtrationfiltered
  4. customdried
  5. additionThe crude compound was charged on a silica gel column (Biotage SP1 system)
  6. washeluted with Cyclohexane/EtOAc (from 100/0 to all 0/100)

출처 및 근거

ORD 기록
ord-62ce0eca3bda4c52840c4cf170ea354d
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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