Hydrochloric Acid → 1-(2,6-Dihydroxyphenyl)-2-methyl-1-propanone

HRID 527532노트

반응식

HRID 527532 반응식
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]COC)[C:6]=1[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17].Cl>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]=1[C:15](=[O:19])[CH:16]([CH3:17])[CH3:18]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 679585761-(2,6-Bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone2회

생성물 1

HCID 134833211-(2,6-Dihydroxyphenyl)-2-methyl-1-propanone수율 86.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone (Intermediate 36, 1.58 g, 5.89 mmol) was dissolved in methanol (40.0 ml) and an aqueous solution of HCl (23.6 mL of a 2M aqueous solution, 47.1 mmol) was added. The reaction mixture was refluxed for 1 hour. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (916 mg).

후처리

  1. temperatureThe reaction mixture was refluxed for 1 hour
  2. customAfter quenching with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe gathered organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-cd3b80daa5fa4eb7989f5606870afe0e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

반응 노트

불러오는 중…