Acetic Anhydride → HCID 67958188, 화합물

HRID 527544

반응식

HRID 527544 반응식
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>ClCCl>[C:10]([O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([OH:8])[C:2]=1[Br:1])(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 6048102-Bromoresorcinol

생성물 1

HCID 67958188HCID 67958188, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-bromo-1,3-benzenediol (3.028 g, 16.02 mmol) in dichloromethane (70 ml), TEA (3.35 ml, 24.03 mmol) and acetic anhydride (1.512 ml, 16.02 mmol) were added under stirring. The reaction mixture was stirred at room temperature overnight. The reaction was quenched with a saturated solution of ammonium chloride (100 ml), and extracted with ethyl acetate (3 times 70 ml). The combined organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound as a black oil which was used directly used in the next step. (3.028 g)

후처리

  1. stirringThe reaction mixture was stirred at room temperature overnight
  2. customThe reaction was quenched with a saturated solution of ammonium chloride (100 ml)
  3. extractionextracted with ethyl acetate (3 times 70 ml)
  4. dry with materialThe combined organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-1817205af72a44ac9f44e75cec3b4ab0
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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