Hydrazine hydrate (1:1) → 6-[(3-methyl-3,4-dihydro-2H-chromen-5-yl)oxy]-3-pyridinamine

HRID 527590노트

반응식

HRID 527590 반응식
O.NN.[CH3:4][CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[O:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][N:17]=2)[O:7][CH2:6]1>C(O)C.[Pd]>[CH3:4][CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[O:15][C:16]2[N:17]=[CH:18][C:19]([NH2:22])=[CH:20][CH:21]=2)[O:7][CH2:6]1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 679583282-[(3-methyl-3,4-dihydro-2H-chromen-5-yl)oxy]-5-nitropyridine2회

생성물 1

HCID 679585226-[(3-methyl-3,4-dihydro-2H-chromen-5-yl)oxy]-3-pyridinamine수율 81.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

In a 50 ml round-bottomed flask 2-[(3-methyl-3,4-dihydro-2H-chromen-5-yl)oxy]-5-nitropyridine (Intermediate 118, 181 mg) was dissolved in ethanol (10 ml) to give a pale yellow solution. Pd/C (33.0 mg, 0.031 mmol) and hydrazine hydrate (0.030 ml, 0.310 mmol) were added. The reaction mixture was stirred at 90° C. After 1 hour, the reaction mixture was filtered and evaporated under vacuum to give the title compound (131.4 mg).

후처리

  1. customto give a pale yellow solution
  2. filtrationthe reaction mixture was filtered
  3. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-4876bf9f11934fcb81c82154038dee93
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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