Ethyl (chloroformyl)acetate → Ethyl thiazole-5-carboxylate

반응식

Cl[CH:2]([CH:8]=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH:10]([NH2:12])=[S:11]>>[C:3]([C:2]1[S:11][CH:10]=[N:12][CH:8]=1)([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

반응물 2

HCID 118030Ethyl (chloroformyl)acetate

HCID 3005587Methanethioamide

생성물 1

HCID 459108Ethyl thiazole-5-carboxylate수율 33%

실험 절차

According to the procedure of Mashraqui and Keehn (J. Am. Chem. Soc. 1982, 104, 4461), ethyl α-chloro-α-formylacetate was condensed with thioformamide and vacuum distilled to provide 5.65 g (33%) of the desired compound.

후처리

distillationdistilled

출처 및 근거

ORD 기록: ord-f3518c71ebc14df68b241e1171fe4697
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05616714

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