Hydrochloric Acid → Hydrochloric Acid

HRID 528711노트

반응식

HRID 528711 반응식
C(OC([N:8]1[CH2:28][CH2:27][C:12]2=[C:13]([N:20]3[CH2:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[ClH:29]>C(Cl)Cl.O1CCOCC1>[O:23]1[CH2:24][CH2:25][CH2:26][N:20]([C:13]2[N:14]3[C:18]([N:19]=[C:11]4[CH2:10][CH2:9][NH:8][CH2:28][CH2:27][C:12]=24)=[CH:17][CH:16]=[N:15]3)[CH2:21][CH2:22]1.[ClH:29]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 6797938810-[1,4]Oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

생성물 2

HCID 313Hydrochloric AcidHCID 6745769810-[1,4]Oxazepan-4-yl-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To 88 mg (0.23 mmol) 10-[1,4]oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in 3 mL DCM, was added 1.13 mL (4.5 mmol) HCl in dioxane (4 M), and the reaction was stirred at room temperature for 16 hours. The solvent was evaporated to give the desired product as a HCl salt.

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-239ee4685529420a835d4895f16f8cae
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346816B2

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