Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (+-)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde | HCID 4692112 | — |
| 반응물 | (1Z)-1-diazo-1-diethoxyphosphorylpropan-2-one | HCID 136104435 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-Butyl 3-ethynylpyrrolidine-1-carboxylate | HCID 54012212 | — |
반응 단계
To 1.23 g (6.17 mmol) 3-Formyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL dry MeOH was added at room temperature 1.42 g (7.41 mmol) (1-Diazo-2-oxo-propyl)-phosphonic acid diethyl ester and 1.71 g (12.4 mmol) K2CO3 and stirring was continued for 2 h. 10 g of silica gel was added to the reaction mixture, stirring continued for 20 min and then filtered. After evaporation of the solvent the residue was purified by column chromatography (silica, cyclohexane/EtOAc 1:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346816B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-b66536a3de4d4670aac403b60817204e |
| 출처 메모 | uspto-grants-2016_05 |