Hydrochloric Acid → 4,4-Difluoro-perhydro-azepinium chloride

HRID 528780노트

반응식

HRID 528780 반응식
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][C:11]([F:16])([F:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:17]>>[Cl-:17].[F:15][C:11]1([F:16])[CH2:12][CH2:13][CH2:14][NH2+:8][CH2:9][CH2:10]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 58110242Tert-butyl 4,4-difluoroazepane-1-carboxylate

생성물 1

HCID 674556284,4-Difluoro-perhydro-azepinium chloride

실험 절차

To 830 mg (3.53 mmol) of 4,4-Difluoro-perhydro-azepine-1-carboxylic acid tert-butyl ester was added 5 mL of 2 M aq. HCl and stirring was continued overnight at room temperature. The reaction mixture was freeze dried and used for the next step without further purification

후처리

  1. customdried
  2. customused for the next step without further purification

출처 및 근거

ORD 기록
ord-e2a839af5d554d9aadeda1c107cbe790
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346816B2

반응 노트

불러오는 중…