Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 529208노트

반응식

HRID 529208 반응식
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

생성물 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride수율 95%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To the compound (0.50 g, 1.8 mmol) obtained in step 1 were added water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol). Acetonitrile (10 ml) was added to dissolve the mixture, and the solution was concentrated under reduced pressure, and lyophilized to give the title compound (0.54 g, 1.7 mmol, 95%).

후처리

  1. dissolutionto dissolve the mixture
  2. concentrationthe solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9c7fe5a3e3b24d4d85ca86f0be782854
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346821B2

반응 노트

불러오는 중…