Sodium Hydroxide → HCID 178440149, 화합물

HRID 52979노트

반응식

[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:31][CH2:32][CH3:33])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]#[N:12])[CH:3]([CH3:5])[CH3:4].[OH-:34].[Na+]>>[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:31][CH2:32][CH3:33])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]([NH2:12])=[O:34])[CH:3]([CH3:5])[CH3:4]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 178440147HCID 178440147, 화합물

생성물 1

HCID 178440149HCID 178440149, 화합물

실험 절차

Following a procedure similar to that described in Example 74(d), but using 0.90 g of 4-(1-hydroxy-2-methylpropyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile [prepared as described in step (c) above] in a 1N aqueous solution of sodium hydroxide, 0.64 g of the title compound was obtained as a powder, melting at 153°-157° C.

출처 및 근거

ORD 기록: ord-5e594e68fa8c43478e97a06a31cd27a2
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05616599

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