N-Hydroxyphthalimide → 2-(cyclopropylmethoxy)-1H-isoindole-1,3(2H)-dione

HRID 530072노트

반응식

HRID 530072 반응식
[OH:1][N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].[CH:13]1([CH2:16]O)[CH2:15][CH2:14]1>>[CH:13]1([CH2:16][O:1][N:2]2[C:3](=[O:12])[C:4]3[C:5](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:7])[CH2:15][CH2:14]1

참가 물질

3

반응물 2

HCID 10665N-HydroxyphthalimideHCID 75644Cyclopropanemethanol

생성물 1

HCID 14843102-(cyclopropylmethoxy)-1H-isoindole-1,3(2H)-dione수율 87%

실험 절차

N-Hydroxyphthalimide and cyclopropyl-methanol were reacted as described for compound LIX in Example 27, to afford LXXXVI in 87% yield. 400 MHz 1H NMR (DMSO-d6, ppm) 7.86 (4H, s), 3.97 (2H, d, J=7.4 Hz), 1.22-1.11 (1H, m), 0.61-0.48 (2H, m), 0.34-0.22 (2H, m).

후처리

  1. customto afford LXXXVI in 87% yield

출처 및 근거

ORD 기록
ord-8b471e50c8d84325a94467e873c8ee7d
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351972B2

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