Dimethylformamide → (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide

HRID 530198노트

반응식

HRID 530198 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@@H:9]([N:11]([CH3:20])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH3:21]N(C)C=O.C[I:27]>C(OCC)(=O)C>[I-:27].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@@H:9]([N+:11]([CH3:21])([CH3:20])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 42604949(S)-1-(3-methoxyphenyl)-N-methyl-N-((S)-1-phenylethyl)ethanamine2회

생성물 1

HCID 86712417(S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide수율 70%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
60 °C

실험 절차

Mix 5.5 g (0.02 mol) of (S)-1-(3-methoxyphenyl)-N-methyl-N—((S)-1-phenylethyl)ethanamine (formula IV) with 12 ml N,N-dimethylformamide and 14.2 g (0.1 mol) of methyl iodide at room temperature, heat the mixture to 60° C. for 12 hours. Let it cool to room temperature, and add 100 ml of ethyl acetate. A yellow solid is produced. Filter and dry it to receive 5.8 g light yellow solid with a yield of 70%.

후처리

  1. temperaturecool to room temperature
  2. customA yellow solid is produced
  3. filtrationFilter
  4. customdry it

출처 및 근거

ORD 기록
ord-f7402d137daa429dbf07c8d59ebf21e4
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353049B2

반응 노트

불러오는 중…