Water → 6-BROMO-8-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE

HRID 530332노트

반응식

HRID 530332 반응식
C1C(=O)N([Br:8])C(=O)C1.[F:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19]=1[NH:18][C:17](=[O:20])[CH2:16][CH2:15]2.O>CN(C=O)C>[Br:8][C:12]1[CH:13]=[C:14]2[C:19](=[C:10]([F:9])[CH:11]=1)[NH:18][C:17](=[O:20])[CH2:16][CH2:15]2

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 151448738-Fluoro-1,2,3,4-tetrahydroquinolin-2-one

생성물 1

HCID 709774606-BROMO-8-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE수율 85%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

NBS (0.62 g, 3.5 mmol) dissolved in DMF (5 mL) was added to a solution of 8-fluoro-3,4-dihydro-1H-quinolin-2-one (0.52 g, 3.2 mmol) in DMF (5 mL) dropwise at 0° C. The resulting reaction mixture was stirred at room temperature for 12 hr before it was treated with water. The precipitated solid was collected through filtration, washed with ether, and dried over vacuum to afford title compound (0.65 g, 85% yield) as a white solid. MS: 244.1 (M+H)+.

후처리

  1. customThe resulting reaction mixture
  2. filtrationThe precipitated solid was collected through filtration
  3. washwashed with ether
  4. customdried over vacuum

출처 및 근거

ORD 기록
ord-613b7bfc057f4b0e91bdc85ec7895afb
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353081B2

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