Hydrochloric Acid → 6-[1-(2-Amino-ethyl)-1,2,3,4-tetrahydro-[1,7]naphthyridin-5-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride

HRID 530352노트

반응식

HRID 530352 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[C:19]2[C:14](=[C:15]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]([CH3:30])[C:25](=[O:31])[CH2:24][CH2:23]4)[CH:16]=[N:17][CH:18]=2)[CH2:13][CH2:12][CH2:11]1)(C)(C)C.[ClH:33].O1CCOCC1>CO>[ClH:33].[NH2:7][CH2:8][CH2:9][N:10]1[C:19]2[C:14](=[C:15]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]([CH3:30])[C:25](=[O:31])[CH2:24][CH2:23]4)[CH:16]=[N:17][CH:18]=2)[CH2:13][CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71536484{2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3,4-dihydro-2H-[1,7]naphthyridin-1-yl]-ethyl}-carbamic acid tert-butyl ester

생성물 1

HCID 715364856-[1-(2-Amino-ethyl)-1,2,3,4-tetrahydro-[1,7]naphthyridin-5-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of {2-[5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3,4-dihydro-2H-[1,7]naphthyridin-1-yl]-ethyl}-carbamic acid tert-butyl ester (example 11, 0.06 g, 0.137 mmol) in MeOH (1 mL) was added 4M HCl in dioxane (0.137 mL, 0.550 mmol) and the reaction mixture was stirred at room temperature over night. Then, the reaction mixture was evaporated to dryness and the solid residue was triturated in diethyl ether, filtered off and further dried on the high vacuum to give the title compound (0.040 g, 70%) as an orange solid. MS: 337.3 (M+H+).

후처리

  1. customThen, the reaction mixture was evaporated to dryness
  2. customthe solid residue was triturated in diethyl ether
  3. filtrationfiltered off
  4. customfurther dried on the high vacuum

출처 및 근거

ORD 기록
ord-8608147ea0bd4f0d8a3c470239f9ef9e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353081B2

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