4,4'-Dimethoxybenzil → 4,4'-Dihydroxybenzil

HRID 530417

반응식

HRID 530417 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[O:12])=[O:10])=[CH:5][CH:4]=1>Br.CC([O-])=O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9](=[O:10])[C:11]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[O:12])=[CH:7][CH:8]=1

참가 물질

4

반응물 1

HCID 710434,4'-Dimethoxybenzil

생성물 1

HCID 4582044,4'-Dihydroxybenzil수율 105.9%

시약·촉매·용매 2

HCID 175Acetate용매HCID 260Hydrogen Bromide용매

실험 절차

4,4′-dimethoxybenzil (2.0 g, 7.41 mmol) was dissolved in 30 mL of hydrogen bromide and 10 mL of acetic acid glacial. The reaction was stirred at reflux temperature overnight. The mixture was extracted with ethyl acetate and the organic phase was washed with water, dried over sodium sulphate. Concentration under vaccum gave the title compound as a yellow solid (1.9 g, quantitative).

후처리

  1. temperatureat reflux temperature overnight
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic phase was washed with water
  4. dry with materialdried over sodium sulphate
  5. concentrationConcentration under vaccum

출처 및 근거

ORD 기록
ord-4a62e416177a4f4ebd82c7f82b8a06e7
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353089B2

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