Methyl iodide → 1-Bromo-3-methoxy-5-methylbenzene
반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([O:9][CH3:10])[CH:3]=1참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
To a mixture of 3-bromo-5-methyl-phenol (185 g; 0.940 mol) and K2CO3 (437 g, 3.17 mol) in acetone (2 L) is added MeI (424 g, 2.99 mol). The mixture is stirred at 40° C. for 16 h. The mixture is cooled to ambient temperature, filtered, and concentrated under reduced pressure. After filtration, the mixture is purified by flash silica gel chromatography to afford 1-Bromo-3-methoxy-5-methyl-benzene, D-4-1 (189 g, quant. yield) as a light yellow oil.
후처리
- temperatureThe mixture is cooled to ambient temperature
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- filtrationAfter filtration
- customthe mixture is purified by flash silica gel chromatography
출처 및 근거
- ORD 기록
- ord-f1abf1cb0fbf45569dbaa2de7aab9ac4
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09353090B2
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