Methyl iodide → 1-Bromo-3-methoxy-5-methylbenzene

HRID 530424

반응식

HRID 530424 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([O:9][CH3:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 126484093-Bromo-5-methylphenol

생성물 1

HCID 106795541-Bromo-3-methoxy-5-methylbenzene

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
40 °C

실험 절차

To a mixture of 3-bromo-5-methyl-phenol (185 g; 0.940 mol) and K2CO3 (437 g, 3.17 mol) in acetone (2 L) is added MeI (424 g, 2.99 mol). The mixture is stirred at 40° C. for 16 h. The mixture is cooled to ambient temperature, filtered, and concentrated under reduced pressure. After filtration, the mixture is purified by flash silica gel chromatography to afford 1-Bromo-3-methoxy-5-methyl-benzene, D-4-1 (189 g, quant. yield) as a light yellow oil.

후처리

  1. temperatureThe mixture is cooled to ambient temperature
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. filtrationAfter filtration
  5. customthe mixture is purified by flash silica gel chromatography

출처 및 근거

ORD 기록
ord-f1abf1cb0fbf45569dbaa2de7aab9ac4
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353090B2

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