ethyl (2S*,3R*)-2-amino-3-hydroxy-pentanoate → (2S,3R)-3-Hydroxynorvaline

HRID 530552노트

반응식

HRID 530552 반응식
[NH2:1][C@@H:2]([C@H:8]([OH:11])[CH2:9][CH3:10])[C:3]([O:5]CC)=[O:4]>Cl>[NH2:1][C@@H:2]([C@H:8]([OH:11])[CH2:9][CH3:10])[C:3]([OH:5])=[O:4]

참가 물질

3

반응물 1

HCID 58287050ethyl (2S*,3R*)-2-amino-3-hydroxy-pentanoate

생성물 1

HCID 10953556(2S,3R)-3-Hydroxynorvaline

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
130 °C

실험 절차

In a 35 ml microwave vial, ethyl (2S*,3R*)-2-amino-3-hydr oxy-pentanoate (0.078 g, 0.48 mmol) was dissolved in a 6.0 M HCl aqueous solution (7.0 mL) and stirred at 130° C. for 30 min. The reaction mixture was concentrated under reduced pressure and the resulting yellowish solid was used without further purification in the following step. MS (ESI) m/z: 134 [M−H]+; (ESI) m/z: 132 [M−H]−.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe resulting yellowish solid was used without further purification in the following step

출처 및 근거

ORD 기록
ord-00dc41e198ae406189081b82ed23bc8a
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353075B2

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