Methanol → Paclitaxel

HRID 53079

반응식

HRID 53079 반응식
CO.C(=O)C1C=CC(OC)=CC=1.S(=O)(=O)(O)O.[CH3:18][C:19]1[C@@H:36]([O:37][C:38]([C@H:40]([OH:57])[C@@H:41]([NH:48][C:49]([C:51]2[CH:52]=[CH:53][CH:54]=[CH:55][CH:56]=2)=[O:50])[C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)=[O:39])[CH2:35][C@:31]2([OH:58])[C:32]([CH3:34])([CH3:33])[C:20]=1[C@@H:21]([O:76][C:77]([CH3:79])=[O:78])[C:22]([C@@:24]1([CH3:75])[C@H:29]([C@@H:30]2[O:59][C:60]([C:62]2[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=2)=[O:61])[C@:28]2([O:70][C:71]([CH3:73])=[O:72])[CH2:68][O:69][C@@H:27]2[CH2:26][C@@H:25]1[OH:74])=[O:23].C/C=C(/C(N[C@H]([C@@H](O)C(O[C@@H]1C(C)=C2C(C)(C)[C@](O)([C@@H](OC(C3C=CC=CC=3)=O)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)C([C@@H]2OC(C)=O)=O)C1)=O)C1C=CC=CC=1)=O)\C>C(Cl)(Cl)Cl>[CH3:18][C:19]1[C@@H:36]([O:37][C:38]([C@H:40]([OH:57])[C@@H:41]([NH:48][C:49]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)=[O:50])[C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)=[O:39])[CH2:35][C@:31]2([OH:58])[C:32]([CH3:33])([CH3:34])[C:20]=1[C@@H:21]([O:76][C:77]([CH3:79])=[O:78])[C:22]([C@@:24]1([CH3:75])[C@H:29]([C@@H:30]2[O:59][C:60]([C:62]2[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=2)=[O:61])[C@:28]2([O:70][C:71]([CH3:73])=[O:72])[CH2:68][O:69][C@@H:27]2[CH2:26][C@@H:25]1[OH:74])=[O:23]

참가 물질

5

반응물 3

HCID 887MethanolHCID 21954228Anisaldehyde sulfuric acidHCID 86586153Paclitaxel cephalomannine

생성물 1

HCID 36314Paclitaxel

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In this fraction, 8 components were identified using 5% it methanol in chloroform as a developing system and p-anisaldehyde/sulfuric acid as a visualizing reagent. Taxol-cephalomannine mixture appeared as a bluish-gray spot, with a Rf value of 0.62.

출처 및 근거

ORD 기록
ord-56026acbb36c44b7b79da23bda29c459
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618538

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