Sodium borohydride → (5-Chloro-6-methylpyridin-2-YL)methanamine

HRID 530802노트

반응식

HRID 530802 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].[BH4-].[Na+]>CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][NH2:10])=[N:6][C:7]=1[CH3:8]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 573365975-Chloro-6-methylpyridine-2-carbonitrile

생성물 1

HCID 72214042(5-Chloro-6-methylpyridin-2-YL)methanamine

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

실험 절차

To a mixture of 5-chloro-6-methylpicolinonitrile (3) (200 mg, 1.31 mmol) in MeOH (10 mL) was added NaBH4 (150 mg, 3.94 mmol), CoCl2 (5 mg) at room temperature. After 30 min, the mixture was filtered and purified by reverse phase chromatography (X bridge Prep C18OBD, 40-60% MeOH in water with 10 mmol NH4HCO3 modifier) to afford the compound as an oil.

후처리

  1. filtrationthe mixture was filtered

출처 및 근거

ORD 기록
ord-04b217567ed54c7c9f8e2180148604cc
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353104B2

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