Hydrochloric Acid → 5,6-Dimethyl-2-pyridinemethanamine

HRID 530807노트

반응식

HRID 530807 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].Cl.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][NH2:10])=[N:6][C:7]=1[CH3:8]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 224176635,6-Dimethylpyridine-2-carbonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 450795455,6-Dimethyl-2-pyridinemethanamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of compound 3 in Scheme 4-3 (58 mg, 0.44 mmol) in MeOH (5 mL) and 6N HCl (1 mL) was added Pd/C (10 mg) at room temperature, the mixture was filled with hydrogen for three times and stirred overnight. The reaction mixture was filtered through celite and washed with MeOH and the filtrate was concentrated. The residue was concentrated to give compound 4 as a dark brown solid.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed with MeOH
  3. concentrationthe filtrate was concentrated
  4. concentrationThe residue was concentrated

출처 및 근거

ORD 기록
ord-00fbc19929f245a6a70e99e326c1c017
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353104B2

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