Phosphorus tribromide → 3-(Bromomethyl)pyrazolo[1,5-a]pyridine
반응식
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[C:3]([CH2:10]O)[CH:2]=1.P(Br)(Br)[Br:13]>C(Cl)Cl>[Br:13][CH2:10][C:3]1[CH:2]=[N:1][N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=12참가 물질
4
실험 절차
To the solution of pyrazolo[1,5-a]pyridin-3-ylmethanol (2) (50 mg, 0.338 mmol) in DCM (2 mL) was added PBr3 (36.58 mg, 0.135 mmol) at room temperature for 30 min. The reaction solution was used in the next step.
출처 및 근거
- ORD 기록
- ord-11575ae34fdd45909ee7e4de3a874ed3
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09353104B2
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