Hydrochloric Acid → (3-(2-Fluorobenzyl)piperidin-3-yl)methanol
반응식
Cl.[F:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][C:6]1([CH2:19][OH:20])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][C:6]1([CH2:19][OH:20])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1참가 물질
4
실험 절차
Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxylate (0.43 g, 1.33 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 346 mg of crude product was recovered and progressed to the next step without further purification.
후처리
- customUpon reaction completion
- concentrationthe reaction was concentrated
- custom346 mg of crude product was recovered
- customprogressed to the next step without further purification
출처 및 근거
- ORD 기록
- ord-d8fc6c7eb35a4955a9e29ca0a3a4ecf1
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09351965B2
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