Hydrochloric Acid → 3-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

HRID 530885노트

반응식

HRID 530885 반응식
Cl.[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67982981tert-Butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate

생성물 1

HCID 679832113-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate (0.415 g, 1.23 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 337 mg of crude product was recovered and progressed to the next step without further purification.

후처리

  1. customUpon reaction completion
  2. concentrationthe reaction was concentrated
  3. custom337 mg of crude product was recovered
  4. customprogressed to the next step without further purification

출처 및 근거

ORD 기록
ord-b356c715e813422683ff34ee5596f4b2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351965B2

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