Tetrahydrofuran → 4,5-Dicyclopropyl-2-ethoxybenzenemethanol

HRID 531054노트

반응식

HRID 531054 반응식
C1COCC1.[CH:6]1([C:9]2[C:18]([CH:19]3[CH2:21][CH2:20]3)=[CH:17][C:12]([C:13](OC)=[O:14])=[C:11]([O:22][CH2:23][CH3:24])[CH:10]=2)[CH2:8][CH2:7]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH:6]1([C:9]2[C:18]([CH:19]3[CH2:21][CH2:20]3)=[CH:17][C:12]([CH2:13][OH:14])=[C:11]([O:22][CH2:23][CH3:24])[CH:10]=2)[CH2:7][CH2:8]1

참가 물질

6

반응물 4

HCID 8028Tetrahydrofuran2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 90423797Methyl 4,5-dicyclopropyl-2-ethoxybenzoate

생성물 1

HCID 904239324,5-Dicyclopropyl-2-ethoxybenzenemethanol수율 97.6%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A THF (15 mL) solution of methyl 4,5-dicyclopropyl-2-ethoxybenzoate (3.26 g) was added at 0° C. to a mixture of lithium aluminum hydride (1.09 g) and THF (65 mL), and the resultant mixture was stirred at room temperature for 1 hour in a nitrogen atmosphere. Water (1 mL), a 1 M aqueous sodium hydroxide solution (1 mL), and water (3 mL) were added in this order to the reaction mixture at 0° C., and the mixture was filtered through celite. Then, the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to obtain the title compound (2.84 g).

후처리

  1. filtrationthe mixture was filtered through celite
  2. concentrationThen, the filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by silica gel chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-5ec82e1b01784cc8ab4f28c7b3cf4312
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353108B2

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