Hydrochloric Acid → Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

HRID 531091노트

반응식

HRID 531091 반응식
C([O:5]C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][CH2:22][C:21]3[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]=3[C:15]2=[O:32])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33].C(OC(C)C)(C)C>>[OH2:5].[ClH:33].[ClH:33].[O:32]=[C:15]1[N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:23][CH2:22][C:21]2[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]1=2

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 117992199Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate

생성물 1

HCID 131735653Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

실험 절차

Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate (14.9 g) was added to 2M hydrogen chloride (ethanol solution, 167 mL) at room temperature. The mixture was stirred for 4 hours. Diisopropyl ether (1.00 L) was added to the reaction mixture. The mixture was stirred for 30 minutes. The precipitate was collected by filtration, washed with diisopropyl ether, dried under reduced pressure to give the title compound (13.7 g).

후처리

  1. stirringThe mixture was stirred for 30 minutes
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with diisopropyl ether
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-bcbcb6f777bc41a69212bbeda5a28240
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353108B2

반응 노트

불러오는 중…