Trifluoroacetic acid → 5-Bromo-6-cyclopropyl-3-iodopyridin-2-amine

HRID 531445노트

반응식

HRID 531445 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.[I:19]N1C(=O)CCC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([I:19])[C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:9][CH2:10]1

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 120273N-IodosuccinimideHCID 900221395-Bromo-6-cyclopropylpyridin-2-amine

생성물 1

HCID 900227685-Bromo-6-cyclopropyl-3-iodopyridin-2-amine수율 100%

실험 절차

A solution of 5-bromo-6-cyclopropylpyridin-2-amine (2.1 g, 9.81 mmol), trifluoroaceticacid (170 mg, 1.47 mmol), N-iodosuccinimide (2.2 g, 9.81 mmol) stirred at room temperature for 30 minutes. Reaction mass was quenched with water, basified with ammonium hydroxide solution. Solid separated was filtered and dried to get 3.3 g (100% yield) of titled compound. 1H NMR (CDCl3, 300 MHz): δ 7.85 (s, 1H), 4.80-4.65 (bs, 2H), 2.39-2.25 (m, 1H), 1.0-0.90 (m, 4H). MS: m/z=338.9 (M+1).

후처리

  1. customReaction mass
  2. customwas quenched with water
  3. customSolid separated
  4. filtrationwas filtered
  5. customdried

출처 및 근거

ORD 기록
ord-1964b8422f8c46aebd9ca5d09c80cde2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353107B2

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