Sodium Hydroxide → 4-(2,3-Dimethoxyphenyl)4-piperidinylmethanone
반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.[OH-].[Na+]>O>[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1참가 물질
4
실험 절차
The resulting 4-(2,3-dimethoxyphenyl)-4-piperidinyl-methanone trifluoroacetate was dissolved in water, treated with NaOH (10% aqueous) until basic, and extracted three times with dichloromethane. The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated to afford 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone as an oil.
후처리
- extractionextracted three times with dichloromethane
- washThe combined organic layers were washed with brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-086336ea55484573bef3076502ad8c97
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05618824
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