tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate → tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

HRID 532256

반응식

HRID 532256 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:20]([O-])=O)=[C:6]([CH:19]=1)[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14]>CO.[Pd]>[NH2:20][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:19][C:6]=1[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16]

참가 물질

4

반응물 1

HCID 58413346tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate

생성물 1

HCID 58413393tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of tert-butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate (3.1 g) in MeOH (5 ml) was added 10% palladium on carbon (300 mg) and the reaction mixture was hydrogenated at room temperature at 50 psi. The catalyst was filtered off and the filtrate was concentrated in vacuo.

후처리

  1. customwas hydrogenated at room temperature at 50 psi
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-be0d9773c66443df96f624b4727ffac0
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853193B2

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