Hydrochloric Acid → Methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

HRID 532292

반응식

HRID 532292 반응식
[F:1][CH:2]([CH3:12])[CH2:3][O:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][N:6]=1.[CH3:13][O:14][C:15]([C:17]1[S:26][C:20]2[N:21]=[CH:22][N:23]=[C:24](Cl)[C:19]=2[C:18]=1[CH3:27])=[O:16].Cl.CN1CCC(=C2C3C(=CC=CC=3)C=CC3C2=CC=CC=3)CC1>O1CCOCC1>[CH3:13][O:14][C:15]([C:17]1[S:26][C:20]2[N:21]=[CH:22][N:23]=[C:24]([NH:11][C:10]3[C:5]([O:4][CH2:3][CH:2]([F:1])[CH3:12])=[N:6][CH:7]=[CH:8][CH:9]=3)[C:19]=2[C:18]=1[CH3:27])=[O:16]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 2913CyproheptadineHCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 584133852-(2-Fluoropropoxy)pyridin-3-amine

생성물 1

HCID 58413371Methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

2-(2-Fluoropropoxy)pyridin-3-amine (153 mg) was dissolved in dioxane (30 ml), 4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (174.54 mg) and HCl in dioxane (4M; 25 μl) was added. The reactin was stirred at 60° C. for three days. The reaction was concentrated in vacuo.

후처리

  1. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-17e4610e66a64b369dff212b1f766a4b
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853193B2

연결된 노트

불러오는 중…