Sodium hydride → 4-Methoxy-2-(3-methyl-1,2,4-oxadiazol-5-yl)benzenamine
반응식
[H-].[Na+].[C:3](=[N:6][OH:7])([NH2:5])[CH3:4].[NH2:8][C:9]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:10]=1[C:11](OC)=O>O1CCCC1>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:9]([NH2:8])=[C:10]([C:11]2[O:7][N:6]=[C:3]([CH3:4])[N:5]=2)[CH:15]=1참가 물질
5
실험 절차
Sodium hydride (594 mg) was added to a stirred suspension of acetamide oxime (1.0 g) and 4 molecular sieves (4 g) in dry tetrahydrofuran (50 ml) under nitrogen. The mixture was heated at 60° for 30 min then allowed to cool to room temperature. A solution of 2-amino-5-methoxybenzoic acid, methyl ester (2.0 g) in dry tetrahydrofuran (20 ml) was added and the mixture stirred at reflux for 2.5 h. The suspension was allowed to cool, filtered and the filtrate evaporated to give the title compound as a yellow solid (1.64 g)
후처리
- temperatureThe mixture was heated at 60° for 30 min
- temperatureat reflux for 2.5 h
- temperatureto cool
- filtrationfiltered
- customthe filtrate evaporated
출처 및 근거
- ORD 기록
- ord-de14df84f908491bba4e59f0038f2dee
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05618827
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