Hydrochloric Acid → 2-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene

2-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-4-(2-trimethylsilanyl-ethoxymethyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.62 g, 0.12 mmol) was dissolved in MeOH and treated with concentrated HCl (0.37 mL, 1.2 mmol). The reaction mixture was heated at 100° C. for 4 hr. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with MeOH and concentrated under reduced pressure to provide the corresponding 2-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a ]pentalene (0.26 g, 0.09 mmol) as brown solid in 75% yield.

1. temperatureThe solution was cooled to room temperature
2. filtrationthe resultant precipitate was filtered
3. washwashed with MeOH
4. concentrationconcentrated under reduced pressure

ORD 기록

ord-96d7ebd1ea074c6181541d850e15fbfd

출처 데이터셋

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08853207B2