Hydrochloric Acid → 1-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride
반응식
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>CO>[ClH:23].[ClH:23].[CH3:22][O:21][C:20]1[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]2)=[N:16][CH:17]=[CH:18][CH:19]=1참가 물질
5
실험 절차
To 4-(3-methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (335 mg, 1.1 mmol) was added MeOH (3 mL) followed by 4M HCl in dioxane (5 mL, 20 mmol). This was stirred for 15 hours, then concentrated to give the title compound. MS (ES) m/z 208 (M+H+).
후처리
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-68970de082864fc28415ab1918483439
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08853202B2
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