N-bromobutanimide → 8-Bromo-7-methoxy-6-methylquinoline
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][CH:6]=[CH:5]2.C1C(=O)N([Br:21])C(=O)C1>CN(C=O)C.CCOC(C)=O>[Br:21][C:10]1[C:11]([O:12][CH3:13])=[C:2]([CH3:1])[CH:3]=[C:4]2[C:9]=1[N:8]=[CH:7][CH:6]=[CH:5]2참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a stirred solution of 6-methyl-7-methoxy-quinoline (3.0 g, 17.3 mmol) in DMF (20 ml) was added NBS (3.4 g, 19 mmol). The resulting suspension was stirred for 3 h at 60° C. and monitored by LCMS. The reaction mixture was diluted with EtOAc (100 ml) and filtered. The organic layer was washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4 and then purified by flash column chromatography on silica gel to give the desired product (2.9 g, 67%). MS (ES) m/z 251.6 (M+H+).
후처리
- filtrationfiltered
- washThe organic layer was washed with saturated aqueous NaHCO3 and brine
- dry with materialdried over Na2SO4
- custompurified by flash column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-1293a097435f4c13a444c7ad2bc925e1
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08853202B2
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