Sodium Hydroxide → 4-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid

HRID 5329

반응식

HRID 5329 반응식
[OH-].[Na+].[CH3:3][S:4][C:5]1[S:6][C:7]([C:15]([O:17]CC)=[O:16])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1>O.C(O)C.O>[CH2:13]([O:12][C:10]([C:8]1[N:9]=[C:5]([S:4][CH3:3])[S:6][C:7]=1[C:15]([OH:17])=[O:16])=[O:11])[CH3:14]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 15009537Diethyl 2-methylthiothiazole-4,5-dicarboxylate

생성물 1

HCID 150095384-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

At room temperature, a solution of 1.10 g (27.5 mmol) of sodium hydroxide in 10 ml of water was added over a period of one hour to a solution of 7.00 g (25 mmol) of diethyl 2-methylthiothiazole-4,5-dicarboxylate in 100 ml of ethanol/water (2:1). The mixture was stirred for one hour, the solvent mixture was then removed under reduced pressure, the residue was taken up in 100 ml of water, the solution was extracted once with 50 ml of diethyl ether, and the aqueous phase was acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

후처리

  1. customthe solvent mixture was then removed under reduced pressure
  2. extractionthe solution was extracted once with 50 ml of diethyl ether
  3. filtrationThe precipitated product was filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-cac5b60f283041dda7c7abbd2044a9b6
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244867

연결된 노트

불러오는 중…