Oxalyl chloride → Cinnamoyl Chloride

HRID 53350

반응식

HRID 53350 반응식
[C:1]([OH:11])(=O)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)(=O)C([Cl:15])=O>C1(C)C=CC=CC=1>[C:1]([Cl:15])(=[O:11])/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 444539Cinnamic Acid

생성물 1

HCID 5354261Cinnamoyl Chloride수율 135.9%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
0 °C

실험 절차

trans-Cinnamic acid (5 g, 33.7 mmol, Aldrich) was dissolved in toluene (100 mL), and the solution was cooled to 0° C. and flushed with N2. Anhydrous DMF (0.1 mL) was added, followed by oxalyl chloride (8.56 g, 5.88 mL, 67.4 mmol) dropwise over 8 minutes. The mixture was stirred at 0° C. for 1 hour and at room temperature for 1.5 hours. The solvent was removed under vacuum to give the title compound (7.63 g).

후처리

  1. customflushed with N2
  2. additionAnhydrous DMF (0.1 mL) was added
  3. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-5922897b2fd84ef282b4a00b663a2f4c
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618949

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