Hydrochloric Acid → Lurasidone hydrochloride
반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.C([O-])(=O)C([O-])=O.[ClH:42]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.[ClH:42]참가 물질
4
실험 절차
A mixture consisting of acetone (3450 mL) and lurasidone oxalate (432 g) is refluxed until dissolved. Concentrated hydrochloric acid (68 mL) is added, and the mixture is cooled to ambient temperature, and then cooled for three hours at 5° C. The solid is filtered, and 326 g of lurasidone hydrochloride free of impurities exceeding 0.1% is obtained after drying.