Tetrahydrofuran → 6-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-ol

HRID 533939노트

반응식

HRID 533939 반응식
[Br:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2=[O:12])=[C:4]([F:13])[CH:3]=1.C1COCC1.[BH4-].[Na+]>CCO>[Br:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:12])=[C:4]([F:13])[CH:3]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 867151266-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 867151256-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of 6-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-one (0.5 g), THF (1 mL) and EtOH (1 mL) was added NaBH4 (100 mg). After 1 hour the reaction mixture was concentrated and the residue distributed between water and EA. The organic phase was washed with water (3 times), dried (Na2SO4), filtered and concentrated. The residue was purified by preparative HPLC to provide the subtitle compound. MS ESI+: m/z=249 [M+H]+.

후처리

  1. concentrationAfter 1 hour the reaction mixture was concentrated
  2. washThe organic phase was washed with water (3 times)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-e5ef06cd3da54bd6adf90fe761e47c69
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853412B2

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