Ethyl Acetate → HCID 390821, 화합물

To a solution of (R)-1,4-dioxaspiro[4.5]decane-2-carbaldehyde (9.0 g, 59.9 mmol) in THF (120 mL and 60 mL of water) was added hydroxyl amine hydrochloride (3.73 g, 52.9 mmol) and the reaction stirred until clear (10 minutes). Sodium carbonate (2.75 g, 25.9 mmol) was added and the reaction stirred overnight at ambient temperature. The reaction was poured into ethyl acetate (500 mL) and the layers were separated. The organics were washed with water (200 mL), brine (200 mL), dried over magnesium sulfate and concentrated in vacuo to yield (S)-1,4-dioxaspiro[4.5]decane-2-carbaldehyde oxime (9.08 g, 49 mmol, 92.7%).

1. stirringthe reaction stirred overnight at ambient temperature
2. customthe layers were separated
3. washThe organics were washed with water (200 mL), brine (200 mL)
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo

ORD 기록

ord-142df55baa3f4aaebd47793c542ec9fe

출처 데이터셋

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08853409B2