Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate → HCID 178418571, 화합물

HRID 5341노트

반응식

HRID 5341 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24](OC)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:30][CH2:31][CH2:32][NH:33][C:34]1[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=1>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24]([NH:30][CH2:31][CH2:32][NH:33][C:34]4[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=4)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:12][CH2:13]2)[CH:7]=1

참가 물질

4

반응물 2

HCID 19013272Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylateHCID 178418575HCID 178418575, 화합물

생성물 1

HCID 178418571HCID 178418571, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

1.89 g of (4.5 mmols) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate and 0.77 g (5 mmols) of 2-[(2-aminoethyl)amino]pyrimidin-4(1H)-one in 5 ml of n-butanol are introduced into a 25 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 15 hours and then the solvent is evaporated under reduced pressure.

후처리

  1. temperatureThe mixture is heated at the reflux temperature of the solvent for 15 hours
  2. customthe solvent is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-682b7c7c9d9d4c65b29faad31f704d69
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244894

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