O-Xylene → 2-Amino-4'-chlorobiphenyl

HRID 534710노트

반응식

HRID 534710 반응식
C1(C)C(C)=CC=CC=1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N+:22]([O-])=O)=[CH:12][CH:11]=1>[Pt].CC(C)=O>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH2:22])=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 7237O-XyleneHCID 2355494'-Chloro-2-nitro-1,1'-biphenyl

생성물 1

HCID 2622612-Amino-4'-chlorobiphenyl

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 180Acetone용매

반응 조건

온도
100 °C

실험 절차

In a 20 ml autoclave were placed 1 g of xylene, 6 mg of a Pt/C catalyst (containing 1% by weight of Pt with respect to the weight of carbon) and 0.25 g (1 mmol) of 4′-chloro-2-nitrobiphenyl obtained in example 1.4. The mixture was stirred under hydrogen pressure (7-8 bar) at 100° C. until the starting material had disappeared (monitoring via HPLC). After completion of the reaction the mixture was cooled to ambient temperature and diluted with 15 ml of acetone. The catalyst was filtered off and the filtrate was evaporated in vacuo yielding 0.2 g (91% of theory) of the title compound in a purity of 93% (HPLC % by weight).

후처리

  1. customAfter completion of the reaction the mixture
  2. temperaturewas cooled to ambient temperature
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-7edf882425b346a5b8725fcdced879a2
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853455B2

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